SENS Research Foundation is a 501(c)3 public charity that researches comprehensive regenerative medicine solutions for the diseases and disabilities of aging.
SRF leads the way in developing, promoting, and ensuring widespread access to treatments that repair the damage underlying the diseases of aging.
We aim to completely redefine the way the world researches and treats aging and age-related diseases. We want you to reimagine aging.
The foundation’s stated goal is to “transform the way the world researches and treats age-related disease”. It advocates the ‘SENS’ approach, which it describes as “the repair of living cells and extracellular material in situ”, an approach it defines in equal contrast to both geriatric medicine’s focus on specific diseases and infirmities, and biogerontology’s focus on intervention in metabolic processes. It funds research and uses outreach and education in order to expedite the various regenerative medicine research programs that go together to make the SENS project.
In addition to research undertaken in-house at the Research Center in Mountain View, SRF has also taken part in and\or selectively funded extramural research at various other institutions, including but not limited to Yale University, Harvard University, Cambridge University, University of Texas, Rice University and University of Arizona.
SENS Research Foundation subdivide their efforts into seven research strands which correspond to seven categories of cellular damage which accumulate with age: accumulated side effects of metabolism which are eventually fatal.
Seven types of aging damage and SENS research strands:
- Cell loss and cell atrophy — Stem cells and tissue engineering
- Nuclear [epi]mutations — WILT, short for “Whole-body Interdiction of Lengthening of Telomeres”
- Mitochondrial mutations — Allotopic expression of 13 proteins
- Death-resistant cells — Targeted removal
- Extracellular crosslinks — AGE-breaking molecules and tissue engineering
- Extracellular aggregates — Stimulating of the immune system to clear out the aggregates
- Intracellular aggregates — Equipping the lysosome with enzymes capable of degrading the aggregates
SENS Research Foundation has at least one project underway in each of its seven research themes.
Outreach and Education
SRF reaches out to policy makers, potential donors, researchers and volunteers through conferences and public events, most notably the biennial SENS Conferences held at Queens’ College, Cambridge, of which there have been five so far. They also host summer internships and produce online coursework for prospective students.